x, n and m are independently an integral between 1 to 5.ġ.R b is C 1-10 alkyl, pyrrolidin-l-yl, piperidin-l-yl, piperazin-l-yl, morpholin-4-yl, 4-(piperidin-l-yl)piperidin-l-yl, or 4-(piperidin-4-yl)piperidin-l-yl.R C is hydrogen, halo, alkyl, alkenyl, alknyl, O(alkyl), -NHCOR a, -NHC(O)OR a, heterocyclyl or aryl, in which the alkyl is optionally substituted with one or more substituents independently selected from the group consisting of halo, alkyl, haloalkyl, alkenyl C(O)H, OC(O)alkyl, O(aryl), and aryl, in which the aryl is optionally substituted with one or more substituents independently selected from the group consisting of halo, CN, C 1-6 alkyl, N(R c) 2, NO 2, O(alkyl), -OCH 2O-, -O(CH 2) 2O-,pyrrolidinyl, pepiridinyl, piperazinyl, morpholino, and 4-(piperido)piperidinyl.R A and R B are independently H or C 1-C 6 alkyl.R 3 is -NR AR B, or -NHPhR C, or -NR AR B are taken together to form pyrrolidin-l-yl, piperidin-l-yl, piperazin-l-yl, morpholin-4-yl, 4-(piperidin-l-y)piperidin-l-yl, or 4-(piperidin-4-yl)piperidin-l-yl, wherein the piperazin-l-yl or 4-(piperidin-4-yl) piperidin-l-yl is optionally substituted with one or more substituents independently selected from the group consisting of alky, and -(CH 2) nCONH(CH 2) mNR AR B.R 2 is hydrogen, alkyl, cycloalkyl, aryl or heteroaryl, in which the aryl or heteroaryl is optionally substituted with one or more substituents independently selected from the group consisting of C 1-6 alkyl, O(alkyl), halo, cyano, nitro, -N(R c) 2, OCH 2O-, O(CH 2) 2O-, pyrrolidinyl, piperidinyl, piperazinyl, morpholino, and 4-(piperido)piperidinyl.R is hydrogen, alkyl, cycloalkyl, or aryl.R 1 is an alkyl optionally substituted with one or more substituents independently selected from the group consisting of halo, -OR, -O(CO)CH 3, -OSO 2R, and -OCONHR.

Optionally substituted with one or more substituents independently selected from the group consisting of halo, alkyl, haloalkyl, alkenyl, C(O)H, OH, O(alkyl), O(CO)alkyl, O(aryl), aryl, and -O(CH 2) xN(R b) 2 The bifunctional compound disclosed herein has the structure of formula (I), Disclosed herein are novel bifunctional compounds and their uses for the treatment and/or prophylaxis of cancers.

2 acetyl pyridine inmr